Protracted febrile myalgia in patients with familial Mediterranean fever

J Rheumatol. 1994 Sep;21(9):1708-9.


Objective: We describe a newly defined syndrome of protracted febrile myalgia in patients with familial Mediterranean fever (FMF).

Methods: Fourteen patients with FMF were admitted with an attack of severe disabling myalgia accompanied by fever, high erythrocyte sedimentation rate, and hyperglobulinemia, lasting up to 6 weeks.

Results: Unlike in the classical manifestations of FMF response to corticosteroids therapy was prompt.

Conclusion: Protracted febrile myalgia is an uncommon dramatic manifestation of FMF that may occur despite colchicine therapy and requires treatment with corticosteroids.

MeSH terms

  • Adolescent
  • Adult
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Child
  • Child, Preschool
  • Colchicine / therapeutic use
  • Drug Therapy, Combination
  • Familial Mediterranean Fever / complications*
  • Familial Mediterranean Fever / drug therapy
  • Female
  • Humans
  • Male
  • Middle Aged
  • Muscular Diseases / drug therapy
  • Muscular Diseases / etiology*
  • Pain / drug therapy
  • Pain / etiology
  • Prednisone / therapeutic use


  • Anti-Inflammatory Agents, Non-Steroidal
  • Colchicine
  • Prednisone