Combined effects of diltiazem and oxygen in pulmonary hypertension of mixed connective tissue disease

J Rheumatol. 1994 Sep;21(9):1763-5.


A 45-year-old woman with pulmonary hypertension and mixed connective tissue disease (MCTD) underwent right heart catheterization to evaluate the effects of vasodilators. Nasal oxygen at 2 l/min in addition to 300 mg diltiazem improved pulmonary hemodynamics without adverse effects. After 1 year of diltiazem and home oxygen, sustained favorable hemodynamic effects were obtained, which were more marked than the acute effects. We conclude that this combination may be a potent treatment for pulmonary hypertension in patients with MCTD.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Combined Modality Therapy
  • Diltiazem / therapeutic use*
  • Drug Therapy, Combination
  • Female
  • Humans
  • Hypertension, Pulmonary / drug therapy
  • Hypertension, Pulmonary / etiology
  • Hypertension, Pulmonary / therapy*
  • Mixed Connective Tissue Disease / complications*
  • Oxygen Inhalation Therapy*


  • Diltiazem