Cognitive behavioural therapy for drug-resistant psychosis

Br J Med Psychol. 1994 Sep;67 ( Pt 3):259-71. doi: 10.1111/j.2044-8341.1994.tb01795.x.


A small controlled trial of cognitive behaviour therapy for drug-resistant psychosis is reported. The study was designed as a pilot study for a future larger and longer randomized controlled trial. The therapy was offered to patients with a diagnosis of schizophrenia or schizo-affective psychosis who presented unremitting positive symptoms. An average of 16 sessions were delivered over a six-month period. The results of this pilot study are promising. Rates of engagement in therapy were high. The treatment group also improved significantly on a number of key symptom measures when compared with the controls. These were reductions in delusional conviction, general symptomatology and depression scores. Future studies should offer therapy over a longer period, targeting social as well as symptom change, and considering factors which will enhance maintenance of improvement.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activities of Daily Living / psychology
  • Adult
  • Aged
  • Antipsychotic Agents / adverse effects
  • Antipsychotic Agents / therapeutic use*
  • Chronic Disease
  • Cognitive Behavioral Therapy*
  • Combined Modality Therapy
  • Delusions / psychology
  • Delusions / rehabilitation
  • Drug Resistance
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Personality Assessment
  • Pilot Projects
  • Psychiatric Status Rating Scales
  • Psychotic Disorders / psychology
  • Psychotic Disorders / rehabilitation*
  • Schizophrenia / rehabilitation*
  • Schizophrenic Psychology*
  • Social Adjustment


  • Antipsychotic Agents