Calcium/calmodulin-dependent protein kinases

Semin Cancer Biol. 1994 Aug;5(4):295-303.

Abstract

Ca2+ is widely recognized as an essential intracellular second messenger in eukaryotic systems regulating processes such as muscle contraction, neurotransmitter release, gene expression and cell proliferation. The effects of Ca2+ are frequently mediated via interaction with calmodulin (CaM) and strong evidence indicates, in turn, that the effects of Ca2+/CaM are often achieved through the regulation of protein phosphorylation. A family of CaM-dependent protein kinases has been identified that includes: myosin light chain kinase, phosphorylase kinase, CaM kinase I, CaM kinase II, EF-2 kinase (CaM kinase III) and CaM kinase IV. The structure, regulation and function of this important family of second messenger-regulated protein kinases will be briefly reviewed.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Calcium-Calmodulin-Dependent Protein Kinase Type 1
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2
  • Calcium-Calmodulin-Dependent Protein Kinase Type 4
  • Calcium-Calmodulin-Dependent Protein Kinases / chemistry
  • Calcium-Calmodulin-Dependent Protein Kinases / physiology*
  • Elongation Factor 2 Kinase
  • Humans
  • Molecular Sequence Data
  • Myosin-Light-Chain Kinase / physiology
  • Phosphorylation

Substances

  • EEF2K protein, human
  • CAMK1 protein, human
  • CAMK4 protein, human
  • Calcium-Calmodulin-Dependent Protein Kinase Type 1
  • Calcium-Calmodulin-Dependent Protein Kinase Type 2
  • Calcium-Calmodulin-Dependent Protein Kinase Type 4
  • Calcium-Calmodulin-Dependent Protein Kinases
  • Myosin-Light-Chain Kinase
  • Elongation Factor 2 Kinase