Malignant lymphoma of the esophagus associated with macroglobulinemia: report of a case

Pathol Int. 1994 Sep;44(9):712-5. doi: 10.1111/j.1440-1827.1994.tb02951.x.


A case of non-Hodgkin's lymphoma of the esophagus in a 74 year old man is presented. Grossly, the surgically removed esophagus had a fusiform submucosal mass covered with smooth surfaced mucosa. Microscopic examination revealed that the mass consisted of a dense infiltrate of small to medium-sized lymphoid cells with plasmacytoid differentiation, leading to a diagnosis of diffuse small cell lymphoma with lymphoplasmacytic subtype. Laboratory data as well as immunohistochemical studies proved that the lymphoma produced monoclonal immunoglobulin M, giving rise to macroglobulinemia.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Esophageal Neoplasms / immunology*
  • Esophageal Neoplasms / pathology
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / immunology*
  • Leukemia, Lymphocytic, Chronic, B-Cell / pathology
  • Male
  • Waldenstrom Macroglobulinemia / etiology*