Hepatitis B vaccination and screening for markers at a sexually transmitted disease clinic for men

Can J Public Health. 1994 Sep-Oct;85(5):338-41.


In Ontario, persons with multiple sexual partners became eligible for free hepatitis B vaccine in late 1991. From January 1992 to January 1993, a sexually transmitted disease (STD) clinic for men in Toronto was one site where the vaccine was delivered. The objectives of the study were to determine the seroprevalence of hepatitis B markers, the series completion rate for hepatitis B vaccine, and the seroprevalence of hepatitis B markers required before screening would be a cost-effective endeavour. The seroprevalence of anti-HBs in gay/bisexual men was 18.1% (95% CI: 15.3%-20.7%) and in heterosexual men was 5.1% (95% CI: 3.0-9.7%). HBsAg was detected in 0.9% (95% CI: 0.04%-1.8%) of gay/bisexual men and was undetected in heterosexual men. Completion of a full vaccine series was 47% for gay/bisexual men and 25% for heterosexual men (p = 0.04). A combined seroprevalence of HBsAg and anti-HBs of at least 30-64%, depending on cost figures used, was required to justify screening prior to completion of a full series.

Publication types

  • Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Community Health Centers
  • Cost-Benefit Analysis
  • Hepatitis B / blood
  • Hepatitis B / complications
  • Hepatitis B / epidemiology*
  • Hepatitis B / prevention & control*
  • Hepatitis B Vaccines*
  • Humans
  • Male
  • Mass Screening / economics
  • Mass Screening / methods*
  • Middle Aged
  • Ontario / epidemiology
  • Prevalence
  • Program Evaluation
  • Prospective Studies
  • Seroepidemiologic Studies
  • Sexual Behavior
  • Sexually Transmitted Diseases / complications*
  • Sexually Transmitted Diseases / epidemiology
  • Vaccination / economics
  • Vaccination / standards*


  • Hepatitis B Vaccines