Total synthesis of ardisiaquinone A, a potent 5-lipoxygenase inhibitor, isolated from Ardisia sieboldii, and degree of 5-lipoxygenase inhibitory activity of its derivatives

Chem Pharm Bull (Tokyo). 1994 Oct;42(10):2211-3. doi: 10.1248/cpb.42.2211.

Abstract

Ardisiaquinone A (1), isolated as a potent 5-lipoxygenase inhibitor from the woods of Ardisia sieboldii, has been synthesized efficiently via a cross-coupling reaction between the yne 5 and the iodide 6 derived from the common intermediate 4. Inhibitory activity for 1 and its derivatives is also reported.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzoquinones / chemical synthesis*
  • Benzoquinones / pharmacology
  • Cross-Linking Reagents
  • Guinea Pigs
  • Lipoxygenase Inhibitors*
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology
  • Quinones / chemistry
  • Structure-Activity Relationship

Substances

  • Benzoquinones
  • Cross-Linking Reagents
  • Lipoxygenase Inhibitors
  • Plant Extracts
  • Quinones
  • ardisiaquinone A