Abstract
Ardisiaquinone A (1), isolated as a potent 5-lipoxygenase inhibitor from the woods of Ardisia sieboldii, has been synthesized efficiently via a cross-coupling reaction between the yne 5 and the iodide 6 derived from the common intermediate 4. Inhibitory activity for 1 and its derivatives is also reported.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Benzoquinones / chemical synthesis*
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Benzoquinones / pharmacology
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Cross-Linking Reagents
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Guinea Pigs
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Lipoxygenase Inhibitors*
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Quinones / chemistry
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Structure-Activity Relationship
Substances
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Benzoquinones
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Cross-Linking Reagents
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Lipoxygenase Inhibitors
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Plant Extracts
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Quinones
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ardisiaquinone A