Determination of the normal range of furosemide half-clearance times when using Tc-99m MAG3

Clin Nucl Med. 1994 Oct;19(10):880-2. doi: 10.1097/00003072-199410000-00008.


In radionuclide diuresis renography, furosemide half-clearance times have been established using Tc-99m DTPA but have not been verified when Tc-99m MAG3 is used. One hundred and six consecutive diuretic renograms using Tc-99m MAG3 for the evaluation of unilateral renal abnormalities were assessed. The furosemide half-clearance times of the normal kidneys were all less than 9.8 minutes, with a mean of 3.4 minutes. In 18 patients, the half-clearance times of the normal kidney were artificially prolonged because urine had drained before the administration of the diuretic. The normal furosemide half-clearance time values obtained using Tc-99m MAG3 were found to be similar to those established for Tc-99m DTPA. Prolonged half-clearance times of Tc-99m MAG3 must be confirmed by visual evidence of obstruction.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Child
  • Female
  • Furosemide* / pharmacokinetics
  • Half-Life
  • Humans
  • Male
  • Radioisotope Renography / methods*
  • Reference Values
  • Technetium Tc 99m Mertiatide*
  • Technetium Tc 99m Pentetate


  • Technetium Tc 99m Mertiatide
  • Furosemide
  • Technetium Tc 99m Pentetate