Ionizing radiation-induced IL-1 alpha, IL-6 and GM-CSF production by human lung cancer cells

Chin Med J (Engl). 1994 Sep;107(9):653-7.


A cell line derived from human lung cancer (AOI) was employed in the present study. A panel of cytokines were quantified by ELISA technique following cellular exposure to X-irradiation. Tremendous increase in the levels of both IL-1 alpha and IL-6 were observed, GM-CSF was also detected. A comparison of time kinetics of IL-1 alpha and IL-6 production was made with that of cell cycle progression which was determined by FCM BrdU/DNA bivariate analysis. No cell cycle specific changes were found. The biological implication of radiation-induced cytokine production was discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Cycle
  • Granulocyte-Macrophage Colony-Stimulating Factor / biosynthesis*
  • Granulocyte-Macrophage Colony-Stimulating Factor / radiation effects
  • Humans
  • Interleukin-1 / biosynthesis*
  • Interleukin-1 / radiation effects
  • Interleukin-6 / biosynthesis*
  • Interleukin-6 / radiation effects
  • Lung Neoplasms / immunology*
  • Lung Neoplasms / pathology
  • Tumor Cells, Cultured / radiation effects


  • Interleukin-1
  • Interleukin-6
  • Granulocyte-Macrophage Colony-Stimulating Factor