Direct immunofluorescent monoclonal antibody test was used for the examination of Chlamydia trachomatis at the cervices of 130 pregnant women and women after deliveries for 2-6 months with extragenital condyloma acuminatum and at the palpebral conjunctivae of their 102 newborns and infants. The results show that the rate of cervical infection in pregnant women is 4.92% and the rate of palpebral infection in the newborns 8.57%. After postnatal 2-6 months, the rates were markedly decreased both in the mothers and their infants, being 1.45% and 0%, respectively. Chlamydia trachomatis infection is a new topic in modern perinatal medicine. In the report, the prevention of maternal-infant transmission problem was discussed.