Khusimol, a non-peptide ligand for vasopressin V1a receptors

J Nat Prod. 1994 Oct;57(10):1329-35. doi: 10.1021/np50112a001.

Abstract

In the course of a random screen of various plant extracts, khusimol [1], a non-peptide molecule isolated from the root of Vetiveria zizanioides, was found to competitively inhibit the binding of vasopressin to rat liver V1a receptors (Ki = 50 microM). The 1H- and 13C-nmr spectra of this sesquiterpene alcohol were assigned unambiguously.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arginine Vasopressin / metabolism
  • In Vitro Techniques
  • Ligands
  • Liver / drug effects*
  • Liver / metabolism
  • Magnetic Resonance Spectroscopy
  • Plants / chemistry
  • Polycyclic Sesquiterpenes
  • Rats
  • Receptors, Vasopressin / metabolism*
  • Sesquiterpenes / chemistry
  • Sesquiterpenes / metabolism
  • Sesquiterpenes / pharmacology*

Substances

  • Ligands
  • Polycyclic Sesquiterpenes
  • Receptors, Vasopressin
  • Sesquiterpenes
  • Arginine Vasopressin
  • khusimol