We operated on 20 adult patients with ventricular septal defect (VSD). In 7 of these cases (aged 36 to 51 years, average 42.6 years), VSD was accompanied by sequelae other than pulmonary hypertension. Concomitant procedures in type-I VSD included a suspension of the prolapsed aortic cusp in 2 patients, a repair of the ruptured sinus of Valsalva in 2, and a new procedure for active infective endocarditis, described below, in 2. In this latter procedure, the aortic valve and infected Valsalva sinus were excised, and the pulmonary valve and the right ventricular wall to which the infection had extended were thoroughly debrided. The resulting defect was closed with a single patch, and a prosthetic valve was inserted in the position of the original aortic valve using this patch as part of the annulus. Another patient with the type-II VSD underwent concomitant tricuspid valve replacement for infective endocarditis. In the mean follow-up period of 77.1 months, 6 patients have been doing well in New York Heart Association class I, and the remaining patient with Valsalva repair remained in class II due to dilated cardiomyopathy.