Effect of continuous negative extrathoracic pressure on respiratory mechanics and timing in infants recovering from neonatal respiratory distress syndrome

Pediatr Res. 1994 Sep;36(3):364-72. doi: 10.1203/00006450-199409000-00017.


Changes in respiratory mechanics and timing produced by continuous negative extrathoracic pressure (CNEP) of -0.6 kPa were assessed in 18 infants recovering from neonatal respiratory distress syndrome. The median gestational age was 28 wk (range 24-36 wk). All infants were recruited before discharge from neonatal intensive care and were measured at a median postnatal age of 58 d (range 10-127 d) and a median weight of 2.67 kg (range 1.99-3.77 kg). All had been treated for respiratory distress syndrome; 11 were diagnosed as having chronic lung disease. At the time of the study, all infants were stable breathing room air. There was a significant decrease of the respiratory rate in all but one infant from 63.6 +/- 10.0 to 49.3 +/- 9.1 breaths per min (mean +/- SD) during CNEP. This was predominantly due to a marked prolongation of the expiratory time. Passive respiratory mechanics were assessed using airway occlusion techniques. Whereas respiratory system compliance (Crs) did not change in the infants with a normal baseline measurement, there was a significant improvement of Crs in the 11 infants with low Crs values in atmosphere: In the latter, all of whom were very-low-birth-weight infants, Crs assessed by the multiple occlusion technique (mean +/- SD) corrected for body weight increased from 7.9 +/- 1.5 to 9.4 +/- 1.9 mL.kPa-1.kg-1 in CNEP (p = 0.012). There was no consistent change in respiratory system resistance in this population of 18 infants.(ABSTRACT TRUNCATED AT 250 WORDS)

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Female
  • Humans
  • Infant, Newborn
  • Lung Volume Measurements
  • Male
  • Respiratory Distress Syndrome, Newborn / physiopathology
  • Respiratory Distress Syndrome, Newborn / therapy*
  • Respiratory Mechanics / physiology*
  • Time Factors
  • Ventilators, Negative-Pressure*