Suppression of acute inflammation with liposome associated prostaglandin E1

Prostaglandins. 1994 Sep;48(3):187-95. doi: 10.1016/0090-6980(94)90018-3.


Prostaglandin E1 (PGE1) suppresses leucocyte effector function and reduces inflammation in several animal models of acute and chronic inflammation. A drawback to its use as a therapeutic agent is the relatively high doses needed to suppress inflammation. We present evidence in this report that liposome associated PGE1 (LAP) reduces markedly acute inflammation induced in a subcutaneous air pouch by monosodium urate crystals, and by the polypeptide mediators, interleukin 1-beta (IL-1 beta) and tumor necrosis factor alpha (TNF alpha). A single dose of 12 micrograms/kg LAP given intravenously 2 hr after inflammation was induced, reduced accumulation of cells and exudate by 31-49%.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acute Disease
  • Animals
  • Dinoprostone / therapeutic use*
  • Inflammation / drug therapy*
  • Interleukin-1 / physiology
  • Liposomes*
  • Male
  • Rats
  • Rats, Sprague-Dawley
  • Tumor Necrosis Factor-alpha / physiology


  • Interleukin-1
  • Liposomes
  • Tumor Necrosis Factor-alpha
  • Dinoprostone