RAP1: a protean regulator in yeast

Trends Genet. 1994 Nov;10(11):408-12. doi: 10.1016/0168-9525(94)90058-2.


The yeast protein RAP1 is a sequence-specific DNA-binding protein that binds to many promoters, to two elements that silence mating-type genes, and to [(C)1-3A]n tracts at telomeres. RAP1 is essential for cell viability and can function as either an activator or a repressor of transcription, depending upon the context of its binding site. Recent experiments suggest that its function may be determined by different sets of protein-protein interactions at promoters and silencers. At the ends of chromosomes, RAP1 plays an important role in both silencing (telomere position effect) and telomere structure.

Publication types

  • Review

MeSH terms

  • DNA / metabolism
  • Fungal Proteins / genetics
  • Fungal Proteins / physiology*
  • GTP-Binding Proteins / genetics
  • GTP-Binding Proteins / physiology*
  • Promoter Regions, Genetic
  • Protein Binding
  • Saccharomyces cerevisiae / genetics*
  • Telomere
  • rap GTP-Binding Proteins


  • Fungal Proteins
  • DNA
  • GTP-Binding Proteins
  • rap GTP-Binding Proteins