Membranoproliferative glomerulonephritis associated with hepatitis C virus infection responsive to interferon-alpha

Am J Kidney Dis. 1995 Jan;25(1):67-9. doi: 10.1016/0272-6386(95)90628-2.


A 42-year-old man with hepatitis C virus infection, cryoglobulinemia, hypocomplementemia, and nephrotic syndrome is reported. The kidney biopsy showed membranoproliferative glomerulonephritis. The patient was treated with interferon-alpha for 2 months. After the treatment, serum hepatitis C virus RNA became negative and nephrotic syndrome remitted. Repeat biopsy of the kidney revealed an improvement in renal histology. This case confirms an association between hepatitis C virus infection and membranoproliferative glomerulonephritis and the usefulness of interferon-alpha for treatment.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Glomerulonephritis, Membranoproliferative / pathology
  • Glomerulonephritis, Membranoproliferative / virology*
  • Hepatitis C / complications
  • Hepatitis C / drug therapy*
  • Hepatitis C / pathology
  • Humans
  • Interferon-alpha / therapeutic use*
  • Kidney Glomerulus / pathology
  • Male


  • Interferon-alpha