Interleukin-1 beta inhibits gastric histamine secretion and synthesis in the rat

Am J Physiol. 1994 Dec;267(6 Pt 1):G966-71. doi: 10.1152/ajpgi.1994.267.6.G966.


Interleukin-1 beta (IL-1 beta) is the most potent inhibitor of gastric acid secretion known at present. Although histamine has been shown to be an important mediator of gastric acid secretion, the effect of IL-1 beta on gastric histamine mobilization has not been studied. In the present study, the effects of IL-1 beta on gastric acid secretion and gastric histamine mobilization were investigated in conscious rats with both gastric and vesical fistulas. IL-1 beta (5 micrograms/kg iv) significantly inhibited basal acid secretion but did not affect basal urinary histamine excretion and fundic histidine decarboxylase (HDC) activity. Gastrin-17-I (1 caused a marked increase in acid secretion, urinary histamine secretion, and fundic HDC activity. IL-1 beta (5 micrograms/kg iv) completely inhibited gastrin-induced acid secretion and partially inhibited urinary histamine excretion and fundic HDC activity. Pretreatment with indomethacin (10 mg/kg ip) partially reversed the inhibitory effects of IL-1 beta on gastrin-stimulated fundic HDC activity and acid secretion. These findings indicate that IL-1 beta inhibits gastric histamine mobilization through both prostaglandin-dependent and prostaglandin-independent pathways. Furthermore, it is suggested that the inhibitory action of IL-1 beta on gastric acid secretion is mediated by the inhibition of gastric histamine mobilization.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Female
  • Gastric Acid / metabolism
  • Gastric Mucosa / metabolism*
  • Gastrins / pharmacology
  • Histamine / metabolism*
  • Histidine Decarboxylase / metabolism
  • Indomethacin / pharmacology
  • Interleukin-1 / pharmacology*
  • Prostaglandins / physiology
  • Rats
  • Rats, Wistar
  • Stomach / drug effects


  • Gastrins
  • Interleukin-1
  • Prostaglandins
  • Histamine
  • Histidine Decarboxylase
  • Indomethacin