Calcium signalling in hair cells: multiple roles in a compact cell

Curr Opin Neurobiol. 1994 Aug;4(4):496-502. doi: 10.1016/0959-4388(94)90049-3.


Ca2+ is critical for mechanosensory adaptation, frequency tuning, afferent synaptic transmission, and efferent modulation in hair cells. These four processes involve cytoplasmic Ca2+ in three independent signalling pathways. Recent work suggests that Ca2+ regulates a myosin adaptation motor, and that a mobile Ca2+ buffer is highly concentrated in hair cells. Focal Ca2+ entry and the cytoplasmic Ca2+ buffer help to separate these pathways by limiting the spread of Ca2+ signals.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Calcium / physiology*
  • Hair Cells, Auditory / physiology*
  • Humans
  • Signal Transduction / physiology*


  • Calcium