Treatment of intractable gastrointestinal manifestations of chronic granulomatous disease with cyclosporine

J Pediatr. 1995 Jan;126(1):143-5. doi: 10.1016/s0022-3476(95)70519-8.


Gastrointestinal manifestations of chronic granulomatous disease of childhood include granulomatous inflammatory bowel disease. Severe colitis and perirectal disease developed in a 12-year-old boy with chronic granulomatous disease while he was receiving interferon gamma therapy. The boy had a deficiency of the 22 kd light chain of the cytochrome b heterodimer. After conventional medical therapy proved to be ineffective, a rapid clinical response was obtained to cyclosporine.

Publication types

  • Case Reports

MeSH terms

  • Aspergillus fumigatus / isolation & purification
  • Child
  • Cyclosporine / therapeutic use*
  • Cytochrome b Group / deficiency
  • Granulomatous Disease, Chronic / drug therapy*
  • Humans
  • Interferon-gamma / therapeutic use
  • Male
  • Pneumonia, Bacterial / drug therapy
  • Pneumonia, Bacterial / microbiology
  • Treatment Outcome


  • Cytochrome b Group
  • Interferon-gamma
  • Cyclosporine