Intact survival with transfusion-associated graft-versus-host disease proved by human leukocyte antigen typing of lymphocytes in skin biopsy specimens

R Hentschel; E B Broecker; G Kolde; M Frosch; W Friedrich; W Holzgreve; E Westphal; E Harms

doi:10.1016/s0022-3476(95)70503-1

Intact survival with transfusion-associated graft-versus-host disease proved by human leukocyte antigen typing of lymphocytes in skin biopsy specimens

J Pediatr. 1995 Jan;126(1):61-4. doi: 10.1016/s0022-3476(95)70503-1.

Authors

R Hentschel¹, E B Broecker, G Kolde, M Frosch, W Friedrich, W Holzgreve, E Westphal, E Harms

Affiliation

¹ Department of Pediatrics, University Hospital, Münster, Germany.

PMID: 7815227
DOI: 10.1016/s0022-3476(95)70503-1

Abstract

A transient transfusion-associated graft-versus-host disease occurred in a premature infant of 30 weeks of gestation. We demonstrated donor lymphocytes in a skin biopsy specimen with a two-step immunoperoxidase technique using monoclonal antibodies against human leukocyte antigen determinants specific for the donor. The girl survived and is immunocompetent.

Publication types

Case Reports

MeSH terms

Antibodies, Monoclonal / immunology
Biopsy
Blood Group Incompatibility / diagnosis
Blood Group Incompatibility / immunology
Blood Transfusion, Intrauterine* / adverse effects
Female
Graft vs Host Disease / etiology
Graft vs Host Disease / immunology*
Graft vs Host Disease / mortality
HLA Antigens / immunology*
Humans
Infant, Newborn
Lymphocytes / immunology
Skin / immunology*

Substances

Antibodies, Monoclonal
HLA Antigens