Intact survival with transfusion-associated graft-versus-host disease proved by human leukocyte antigen typing of lymphocytes in skin biopsy specimens

J Pediatr. 1995 Jan;126(1):61-4. doi: 10.1016/s0022-3476(95)70503-1.


A transient transfusion-associated graft-versus-host disease occurred in a premature infant of 30 weeks of gestation. We demonstrated donor lymphocytes in a skin biopsy specimen with a two-step immunoperoxidase technique using monoclonal antibodies against human leukocyte antigen determinants specific for the donor. The girl survived and is immunocompetent.

Publication types

  • Case Reports

MeSH terms

  • Antibodies, Monoclonal / immunology
  • Biopsy
  • Blood Group Incompatibility / diagnosis
  • Blood Group Incompatibility / immunology
  • Blood Transfusion, Intrauterine* / adverse effects
  • Female
  • Graft vs Host Disease / etiology
  • Graft vs Host Disease / immunology*
  • Graft vs Host Disease / mortality
  • HLA Antigens / immunology*
  • Humans
  • Infant, Newborn
  • Lymphocytes / immunology
  • Skin / immunology*


  • Antibodies, Monoclonal
  • HLA Antigens