Formaldehyde induced DNA-protein crosslinks in Escherichia Coli

Mutat Res. 1976 Jul;36(1):11-6. doi: 10.1016/0027-5107(76)90016-6.


Exposure of Escherichia coli to low doses of formaldehyde induces interstrand cross-links in the cellular DNA, at least 50% of which involve protein "bridges" between the DNA strands. The biological importance of these cross-links is suggested by both the high yield of formation and by the inability of some sensitive repair deficient mutants to completely remove cross-links and bound protein from the DNA during post treatment incubation.

MeSH terms

  • Bacterial Proteins
  • DNA Repair
  • DNA, Bacterial*
  • Dose-Response Relationship, Drug
  • Escherichia coli / drug effects*
  • Formaldehyde / pharmacology*
  • Mutation
  • Nucleic Acid Conformation / drug effects*


  • Bacterial Proteins
  • DNA, Bacterial
  • Formaldehyde