Large-cell anaplastic lymphoma-specific translocation (t[2;5] [p23;q35]) in Hodgkin's disease: indication of a common pathogenesis?

Lancet. 1995 Jan 14;345(8942):87-90. doi: 10.1016/s0140-6736(95)90061-6.


Chromosomal aberrations are characteristic and specific events; the detection of chromosomal abnormalities often provides information on diagnosis and prognosis of disease. Some patients with large-cell anaplastic lymphoma (Ki 1 lymphoma) have the translocation t(2;5) (p23; q35), involving a possible growth-regulating tyrosine kinase. We found this translocation in 11 patients with Hodgkin's disease of nodular sclerosis and mixed-cellularity types. This finding has implications for the understanding of the relation between large-cell anaplastic lymphoma and Hodgkin's disease, diseases with morphological and immunophenotypical similarities. Study of this translocation may help understanding of the origins of cancer and cancer growth. It also allows a more precise definition of Hodgkin's disease and may be used as an indicator for clonality--which has long been sought.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actins / genetics
  • Anaplastic Lymphoma Kinase
  • Base Sequence
  • Hodgkin Disease / genetics*
  • Humans
  • Lymphoma, Large-Cell, Anaplastic / genetics*
  • Molecular Sequence Data
  • Nuclear Proteins / genetics
  • Nucleophosmin
  • Polymerase Chain Reaction
  • Protein-Tyrosine Kinases / genetics
  • Receptor Protein-Tyrosine Kinases
  • Transcription, Genetic
  • Translocation, Genetic*


  • Actins
  • Nuclear Proteins
  • Nucleophosmin
  • ALK protein, human
  • Anaplastic Lymphoma Kinase
  • Protein-Tyrosine Kinases
  • Receptor Protein-Tyrosine Kinases