Look-back study of infectivity of anti-HCV ELISA-positive blood components

Lancet. 1995 Jan 14;345(8942):95-6. doi: 10.1016/s0140-6736(95)90063-2.


The infectivity of blood components from donors who were later found to be anti-HCV ELISA-positive was investigated in recipients who were enrolled in a look-back programme. Recipients received ELISA-positive blood components from donors who were PCR-positive and/or RIBA-2-positive (n = 22, group A) or PCR-negative and indeterminate or negative on RIBA-2 (n = 105, group B). 26 of 32 (81%) recipients of group A donors and none of 140 of group B were HCV-infected. All stored serum samples of previous donations (n = 172) of group A donors were anti-HCV-positive in RIBA-3, indicating a chronic carrier state of HCV in these donors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Blood Donors*
  • Contact Tracing
  • Enzyme-Linked Immunosorbent Assay*
  • Hepatitis C / diagnosis*
  • Hepatitis C / transmission*
  • Humans
  • Immunoblotting
  • Polymerase Chain Reaction
  • Transfusion Reaction