Biphasic effect of ethanol on extracellular accumulation of glutamate in the hippocampus and the nucleus accumbens

Neurosci Lett. 1994 Aug 29;178(1):99-102. doi: 10.1016/0304-3940(94)90299-2.


The effect of systemic ethanol administration on the extracellular levels of glutamate in the hippocampus and nucleus accumbens of conscious rats was assessed using microdialysis. At 0.5 g/kg, ethanol caused a sustained increase in the levels of glutamate in both regions. Following 1.0 g/kg, response was observed in the nucleus accumbens while a trend towards a decrease in glutamate levels occurred in hippocampus. Injection of 2.0 g/kg ethanol decreased these levels in both regions. These findings suggest a relationship between the previously reported biphasic behavioral consequence of ethanol and its effect on glutamatergic neurotransmission.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Dose-Response Relationship, Drug
  • Ethanol / administration & dosage
  • Ethanol / pharmacology*
  • Extracellular Space / metabolism
  • Glutamic Acid / metabolism*
  • Hippocampus / drug effects
  • Hippocampus / metabolism*
  • Injections, Intraperitoneal
  • Microdialysis
  • Nucleus Accumbens / drug effects
  • Nucleus Accumbens / metabolism*
  • Rats
  • Time Factors


  • Ethanol
  • Glutamic Acid