Effectiveness of intraoperative mitomycin C in the treatment of recurrent pterygium

Ophthalmologica. 1994;208(5):247-9. doi: 10.1159/000310500.


The effectiveness of intraoperative administration of mitomycin C and the occurrence of postoperative complications have been evaluated in 30 white patients with one recurrence of pterygium. The authors employed the 'bare-sclera technique' and, intraoperatively, placed in the episcleral space for 3 min a sterile sponge soaked in a 4% mitomycin C solution. The control group (30 patients with one recurrent pterygium) underwent only surgical excision. Statistical analysis performed using the chi-square test showed a significant (p = 0.024) reduction of recurrences of pterygium in the group treated intraoperatively with mitomycin C. No heavy side effects occurred during the follow-up period. Mitomycin C, administered intraoperatively, may be considered an effective treatment to improve the success rate after surgical excision.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Drug Evaluation
  • Female
  • Follow-Up Studies
  • Humans
  • Intraoperative Care
  • Male
  • Middle Aged
  • Mitomycin / adverse effects
  • Mitomycin / therapeutic use*
  • Postoperative Complications
  • Pterygium / drug therapy*
  • Pterygium / etiology
  • Pterygium / surgery
  • Recurrence


  • Mitomycin