Prospective, randomized, placebo-controlled, double-blind testing of colour vision and electroretinogram at therapeutic and subtherapeutic digitoxin serum levels

Ophthalmologica. 1994;208(5):259-61. doi: 10.1159/000310503.

Abstract

In a prospective, randomized, double-blind study with 10 healthy probands, changes in colour discrimination and in the pattern electroretinogram (P-ERG) and visually evoked cortical potentials (P-VECP) were monitored at therapeutic and subtherapeutic digitoxin serum levels. There was a slight increase in the total error score in the Farnsworth-Munsell 100-hue test at 0.1 mg digitoxin per day in comparison with the placebo. P-ERG and P-VECP did not show any significant changes.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Color Perception / drug effects
  • Color Perception / physiology*
  • Color Vision Defects / chemically induced
  • Color Vision Defects / physiopathology*
  • Digitoxin / adverse effects*
  • Digitoxin / blood
  • Digitoxin / therapeutic use
  • Double-Blind Method
  • Electroretinography
  • Evoked Potentials, Visual / physiology
  • Humans
  • Male
  • Prospective Studies
  • Radioimmunoassay
  • Retina / drug effects

Substances

  • Digitoxin