A double-blind comparison of vecuronium administered by the Springfusor infusion device to vecuronium by intermittent bolus injection in critically ill adult patients

Anaesth Intensive Care. 1994 Oct;22(5):580-5. doi: 10.1177/0310057X9402200514.


To evaluate the Springfusor infusion device for clinical use in an Intensive Care Unit and to compare the technique of intermittent bolus and constant infusion of muscle relaxants, we undertook a prospective double-blind randomized placebo-controlled study. Twenty critically ill ventilated patients requiring muscle paralysis were investigated. Although we could show no clinical advantage in infusing vecuronium, the Springfusor provided a more constant level of paralysis compared with hourly bolus doses. The device is robust, easy to use and reduces nursing workload. This may translate into cost-saving improvement in patient care if the Springfusor is used to provide muscle relaxation, sedation and analgesia.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Analgesia
  • Anesthesia, Intravenous / instrumentation*
  • Cost Savings
  • Critical Care
  • Critical Illness* / economics
  • Critical Illness* / nursing
  • Double-Blind Method
  • Female
  • Humans
  • Hypnotics and Sedatives / administration & dosage
  • Infusion Pumps*
  • Infusions, Intravenous / instrumentation
  • Male
  • Neuromuscular Junction / drug effects
  • Placebos
  • Prospective Studies
  • Respiration, Artificial
  • Vecuronium Bromide / administration & dosage*


  • Hypnotics and Sedatives
  • Placebos
  • Vecuronium Bromide