Genomic Organization and Chromosomal Location of the Mouse Type I BMP-2/4 Receptor

Biochem Biophys Res Commun. 1995 Jan 5;206(1):310-7. doi: 10.1006/bbrc.1995.1043.

Abstract

We have characterized the structure of a mouse bone morphogenetic protein (BMP) type I receptor gene that can bind both BMP-2 and BMP-4. The mouse BMP-2/4 receptor gene is encoded by 11 exons and spans approximately 38-kb. Most of the intron/exon boundaries are not conserved compared to the kinase domain of the related, activin type II receptor. In addition, whereas the activin type II receptor gene contains large introns (> 40 kb), the largest intron of the BMP-2/4 receptor gene is only 6.4-kb. The BMP-2/4 receptor gene (Bmpr) was mapped to mouse chromosome 14. Bmpr is closely linked to Rbp3 in the region containing pugnose, a mutation that alters bone development. Knowledge of the genomic structure of Bmpr provides important information to create Bmpr-deficient mice.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Bone Morphogenetic Protein Receptors
  • Bone Morphogenetic Proteins
  • Chromosome Mapping*
  • Consensus Sequence
  • Crosses, Genetic
  • Exons
  • Female
  • Introns
  • Male
  • Mice
  • Mice, Inbred C57BL / genetics*
  • Molecular Sequence Data
  • Muridae / genetics*
  • Polymorphism, Restriction Fragment Length
  • Protein Biosynthesis
  • Proteins / metabolism*
  • Receptors, Cell Surface / genetics*
  • Receptors, Cell Surface / metabolism
  • Receptors, Growth Factor*

Substances

  • Bone Morphogenetic Proteins
  • Proteins
  • Receptors, Cell Surface
  • Receptors, Growth Factor
  • Bone Morphogenetic Protein Receptors