The role of T cell receptor beta chain genes in susceptibility to rheumatoid arthritis

Arthritis Rheum. 1995 Jan;38(1):91-5. doi: 10.1002/art.1780380114.


Objective: To evaluate the role of the T cell receptor beta chain locus (TCRB) in genetic susceptibility to rheumatoid arthritis (RA).

Methods: Twenty-eight multiplex RA families were recruited from 3 rheumatology outpatient departments. All members were genotyped for a highly informative microsatellite (V beta 6.7), a V beta 12.2 SSCP marker, and a biallelic C beta restriction fragment length polymorphism. Data were analyzed by the SIBPAL program to assess identity-by-descent in affected sib-pairs.

Results: Using the V beta 12.2 marker, there was suggestive evidence of increased sib-pair sharing (P = 0.005) in affected offspring (a P value of 0.001 is generally taken to establish linkage). Data for V beta 6.7 and C beta yielded significance levels of 0.06 and 0.19, respectively.

Conclusion: These data suggest that a gene in or linked to the TCRB complex may confer genetic susceptibility to RA in these families. Confirmation in a larger panel of families is required.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Alleles
  • Arthritis, Rheumatoid / genetics*
  • Arthritis, Rheumatoid / immunology
  • Disease Susceptibility
  • Female
  • Genetic Markers / genetics
  • Genotype
  • HLA-DR Antigens / analysis
  • HLA-DR Antigens / genetics
  • Humans
  • Male
  • Polymorphism, Restriction Fragment Length
  • Receptors, Antigen, T-Cell, alpha-beta / genetics*


  • Genetic Markers
  • HLA-DR Antigens
  • Receptors, Antigen, T-Cell, alpha-beta