Effect of interleukin 1 receptor antagonist on the blood-aqueous barrier after intraocular lens implantation

Br J Ophthalmol. 1994 Dec;78(12):917-20. doi: 10.1136/bjo.78.12.917.

Abstract

Interleukin 1 (IL-1) possesses as an intercellular signal a wide spectrum of inflammatory, metabolic, haematopoetic, immunological, and reparative properties and can be a mediator not only of host defence but also of disease. Reduction of IL-1 can decrease the inflammatory host response. A human recombinant IL-1 receptor antagonist (IL-1ra) was used to block IL-1 after intraocular lens implantation in rabbits. Seventeen rabbits underwent intercapsular phacoemulsification and posterior chamber lens implantation. A 100 micrograms dose (0.1 ml) of IL-1ra (1 mg/ml) was injected into the anterior chamber at the end of surgery in seven rabbits. The 10 rabbits serving as the controls received no IL-1ra. Postoperatively, all rabbits were observed with a slit-lamp, and the aqueous flare intensity was measured with a laser flare cell meter at 12 hours, 1, 2, 3, and 4 days and thereafter at 1, 2, 3, and 4 weeks. Aqueous flare intensity was significantly lower on days 2 and 3, and fibrin deposition much less marked in the eyes treated with IL-1ra, compared with the controls. The results suggest that IL-1 is involved in the postoperative inflammation that occurs after intraocular lens implantation and the use of the IL-1ra would be valuable for reducing this problem.

MeSH terms

  • Animals
  • Aqueous Humor / drug effects*
  • Eye Diseases / prevention & control
  • Inflammation / prevention & control
  • Lens Capsule, Crystalline / pathology
  • Lenses, Intraocular*
  • Postoperative Complications / prevention & control*
  • Rabbits
  • Receptors, Interleukin-1 / antagonists & inhibitors*
  • Recombinant Proteins
  • Time Factors

Substances

  • Receptors, Interleukin-1
  • Recombinant Proteins