Anti-diabetic activity present in the fruit body of Grifola frondosa (Maitake). I

Biol Pharm Bull. 1994 Aug;17(8):1106-10. doi: 10.1248/bpb.17.1106.


The fruit body of Grifola frondosa (maitake), Basidiomycetes was confirmed to contain substances with anti-diabetic activity. When 1 g/d of powdered fruit body of maitake was given orally to a genetically diabetic mouse (KK-Ay), blood glucose reduction was observed, in contrast to the control group in which the blood glucose increased with ageing. Moreover, levels of insulin and triglyceride in plasma demonstrated a change similar to blood glucose with feeding of maitake. Ether-ethanol-soluble (ES) and hot water-soluble (WS) fractions were prepared from the fruit body and their hypoglycemic activity was examined. Blood glucose-lowering activity was found when ES-fraction or WS-50% ethanol float (X) fraction was administered orally, but other WS-fractions were inactive. These results suggest that the anti-diabetic activity was present not only in the ES-fraction consisting of lipid but also in the X-fraction of peptidoglycan (sugar:protein = 65:35).

MeSH terms

  • Animals
  • Blood Glucose / metabolism*
  • Diabetes Mellitus, Type 2 / drug therapy
  • Diabetes Mellitus, Type 2 / genetics
  • Female
  • Hypoglycemic Agents / pharmacology*
  • Insulin / blood
  • Mice
  • Mice, Inbred Strains
  • Peptidoglycan / metabolism
  • Polyporaceae / chemistry*
  • Triglycerides / blood


  • Blood Glucose
  • Hypoglycemic Agents
  • Insulin
  • Peptidoglycan
  • Triglycerides