The sequence of a human mitochondrial glycerol-3-phosphate dehydrogenase-encoding cDNA

Gene. 1994 Dec 15;150(2):417-8. doi: 10.1016/0378-1119(94)90469-3.

Abstract

A 2618-bp cDNA that encodes the human mitochondrial glycerol-3-phosphate dehydrogenase has been isolated from a HeLa cell cDNA library and the nucleotide sequence determined. An open reading frame encodes a protein of 727 amino acids that is 96% similar to the rat protein and, like the rat protein, contains sites homologous to the Ca(2+)-binding sites of calmodulin, as well as FAD- and putative glycerol-phosphate-binding sites.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Binding Sites
  • Calcium / metabolism
  • Calmodulin / metabolism
  • DNA, Complementary
  • Flavin-Adenine Dinucleotide / metabolism
  • Gene Library
  • Glycerolphosphate Dehydrogenase / genetics*
  • Glycerophosphates / metabolism
  • HeLa Cells
  • Hominidae / genetics*
  • Humans
  • Molecular Sequence Data
  • Open Reading Frames
  • Rats
  • Sequence Homology, Amino Acid

Substances

  • Calmodulin
  • DNA, Complementary
  • Glycerophosphates
  • Flavin-Adenine Dinucleotide
  • Glycerolphosphate Dehydrogenase
  • Calcium

Associated data

  • GENBANK/U12424