Direct immunofluorescence vs. culture for detecting HSV in oral ulcers: a comparison

J Am Dent Assoc. 1995 Jan;126(1):74-8. doi: 10.14219/jada.archive.1995.0026.

Abstract

Diagnostic tests may be necessary to determine the cause of oral ulcers. Direct immunofluorescence staining of oral smears supplies results much more quickly than viral culture, the "gold standard" for diagnosing HSV lesions. This study compares the sensitivity and specificity of direct immunofluorescence staining vs. viral culture and evaluates the usefulness of the two techniques for the general dental practitioner.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Monoclonal
  • Fluorescent Antibody Technique
  • HIV Seropositivity
  • Herpesvirus 1, Human / isolation & purification*
  • Herpesvirus 2, Human / isolation & purification*
  • Humans
  • Male
  • Middle Aged
  • Reagent Kits, Diagnostic
  • Reproducibility of Results
  • Stomatitis, Herpetic / diagnosis*
  • Ulcer / virology
  • Virus Cultivation

Substances

  • Antibodies, Monoclonal
  • Reagent Kits, Diagnostic