[Use of liquid sorbents based on chitosan for treatment of diffuse forms of peritonitis]

Patol Fiziol Eksp Ter. 1994 Jul-Sep;(3):49-50.
[Article in Russian]


Chitosan-based gelatinous affinity sorbent containing 9 mg/ml of polymyxin B was injected into the infected peritoneal cavity for twenty-four hours for detoxification in diffuse peritonitis. The clinical assay of blood plasma (Spectrum Abbot, USA) revealed that the lavage of the infected abdomen by polymyxin B-containing adsorbent resulted in systemic detoxification. The effect was associated with normalization of direct bilirubin, cholesterol, and triglyceride levels, a 4-fold decrease in uric acid levels, and a 34-fold increase in alkaline phosphatase activity, and a greater than 70-fold enhancement of hepatic aspartate aminotransferase activity.

MeSH terms

  • Animals
  • Chitin / analogs & derivatives*
  • Chitin / therapeutic use
  • Chitosan
  • Peritonitis / drug therapy*
  • Polymyxin B / therapeutic use*
  • Rats
  • Rats, Wistar
  • Sorption Detoxification / methods*


  • Chitin
  • Chitosan
  • Polymyxin B