Abstract
A 1-year double-blind crossover study comparing prednisone and azathioprine to prednisone plus low-dose azathioprine and cyclophosphamide was carried out in 14 patients with diffuse lupus nephritis. Low-dose triple therapy had no apparent therapeutic advantage over prednisone plus azathioprine. Cyclophosphamide-induced ovarian failure and hematuria were not avoided by its use in low dose.
Publication types
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Clinical Trial
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Comparative Study
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Controlled Clinical Trial
MeSH terms
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Adolescent
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Adult
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Amenorrhea / chemically induced
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Azathioprine / administration & dosage*
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Azathioprine / adverse effects
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Azathioprine / therapeutic use
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Clinical Trials as Topic
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Cyclophosphamide / adverse effects
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Cyclophosphamide / therapeutic use*
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Drug Therapy, Combination
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Female
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Humans
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Lupus Erythematosus, Systemic / drug therapy*
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Nephritis / drug therapy*
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Prednisone / adverse effects
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Prednisone / therapeutic use*
Substances
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Cyclophosphamide
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Azathioprine
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Prednisone