Prednisone and azathioprine compared to prednisone plus low-dose azathioprine and cyclophosphamide in the treatment of diffuse lupus nephritis

Arthritis Rheum. Jul-Aug 1976;19(4):693-9. doi: 10.1002/1529-0131(197607/08)19:4<693::aid-art1780190406>3.0.co;2-2.

Abstract

A 1-year double-blind crossover study comparing prednisone and azathioprine to prednisone plus low-dose azathioprine and cyclophosphamide was carried out in 14 patients with diffuse lupus nephritis. Low-dose triple therapy had no apparent therapeutic advantage over prednisone plus azathioprine. Cyclophosphamide-induced ovarian failure and hematuria were not avoided by its use in low dose.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Adolescent
  • Adult
  • Amenorrhea / chemically induced
  • Azathioprine / administration & dosage*
  • Azathioprine / adverse effects
  • Azathioprine / therapeutic use
  • Clinical Trials as Topic
  • Cyclophosphamide / adverse effects
  • Cyclophosphamide / therapeutic use*
  • Drug Therapy, Combination
  • Female
  • Humans
  • Lupus Erythematosus, Systemic / drug therapy*
  • Nephritis / drug therapy*
  • Prednisone / adverse effects
  • Prednisone / therapeutic use*

Substances

  • Cyclophosphamide
  • Azathioprine
  • Prednisone