Anti-inflammatory effects of recombinant human manganese superoxide dismutase on adjuvant arthritis in rats

Rheumatol Int. 1994;14(2):77-81. doi: 10.1007/BF00300251.

Abstract

The anti-inflammatory effects of recombinant human manganese superoxide dismutase on adjuvant arthritis was investigated. Local application of this manganese superoxide dismutase given every 2 days not only significantly reduced foot swelling but also retarded radiological bone destruction in adjuvant arthritis. Copper zinc superoxide dismutase had little effect on foot swelling.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
  • Arthritis, Experimental / drug therapy*
  • Half-Life
  • Humans
  • Injections, Intra-Articular
  • Male
  • Rats
  • Rats, Inbred Lew
  • Recombinant Proteins
  • Superoxide Dismutase / administration & dosage*
  • Treatment Outcome

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Recombinant Proteins
  • Superoxide Dismutase