Heat shock protein-peptide complexes in cancer immunotherapy

Curr Opin Immunol. 1994 Oct;6(5):728-32. doi: 10.1016/0952-7915(94)90076-0.


Heat shock proteins (HSPs) are associated with a broad spectrum of peptides derived from the cells from which they are isolated. Vaccination with such HSP-peptide complexes elicits protective immunity against tumors or other cells used as the source of HSPs. These observations suggest that HSP-peptide complexes are suitable as vaccines against cancers and infectious diseases.

Publication types

  • Review

MeSH terms

  • Animals
  • Antigens, Neoplasm / immunology*
  • Heat-Shock Proteins / immunology*
  • Humans
  • Immunotherapy / methods*
  • Neoplasms / immunology
  • Neoplasms / therapy*
  • Vaccines / immunology


  • Antigens, Neoplasm
  • Heat-Shock Proteins
  • Vaccines