The 5-HT1A receptor antagonist (S)-UH-301 blocks the qR)-8-OH-DPAT-induced inhibition of serotonergic dorsal raphe cell firing in the rat

J Neural Transm Gen Sect. 1994;96(3):179-86. doi: 10.1007/BF01294785.

Abstract

(S)-UH-301 [(S)-5-fluoro-8-hydroxy-2-(dipropylamino)-tetralin, 0.5-4.0 mg/kg i.v.] did not significantly alter the firing rate of 5-hydroxytryptamine (5-HT) containing neurons in the dorsal raphe nucleus (DRN) as a group, although some individual cells were activated whereas others were depressed. However, (S)-UH-301 (2.0 mg/kg i.v.) consistently reversed the inhibition of DRN-5-HT cells produced by the selective 5-HT1A receptor agonist (R)-8-OH-DPAT (0.5 microgram/kg i.v.) and the dose-response curve for this effect of (R)-8-OH-DPAT was markedly shifted to the right by pretreatment with (S)-UH-301 (1.0 mg/kg i.v.). These results support the notion that (S)-UH-301 acts as an antagonist at central 5-HT1A receptors.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 8-Hydroxy-2-(di-n-propylamino)tetralin / analogs & derivatives*
  • 8-Hydroxy-2-(di-n-propylamino)tetralin / antagonists & inhibitors*
  • 8-Hydroxy-2-(di-n-propylamino)tetralin / pharmacology
  • Action Potentials / drug effects
  • Animals
  • Dose-Response Relationship, Drug
  • Electrophysiology
  • Male
  • Neurons / drug effects*
  • Raphe Nuclei / cytology
  • Raphe Nuclei / drug effects*
  • Rats
  • Rats, Sprague-Dawley
  • Serotonin / physiology*
  • Serotonin Antagonists / pharmacology*

Substances

  • Serotonin Antagonists
  • UH 301
  • Serotonin
  • 8-Hydroxy-2-(di-n-propylamino)tetralin