Crystal structure of C-T-C-T-C-G-A-G-A-G. Implications for the structure of the Holliday junction

Biochemistry. 1995 Jan 24;34(3):1022-9. doi: 10.1021/bi00003a037.


The structure of the B-DNA decamer of sequence C-T-C-T-C-G-A-G-A-G shows a crossed arrangement of helices in the C2 crystal lattice. This is the fourth example of a crossed arrangement of B-DNA oligomers in a crystal, and in spite of the fact that each of these four crystallizes in a different lattice, all have nearly identical structures at the crossing contact. This ubiquitous crossing arrangement may be used to generate a structure for the Holliday junction that is fully consistent with the available physical data.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Base Sequence
  • Calcium / chemistry
  • Crystallography, X-Ray
  • DNA / chemistry*
  • Molecular Sequence Data
  • Nucleic Acid Conformation*
  • Oligodeoxyribonucleotides / chemistry*
  • Recombination, Genetic


  • Oligodeoxyribonucleotides
  • DNA
  • Calcium