Cesium prevents maintenance of long-term depression in rat hippocampal CA1 neurons

Neuroreport. 1994 Sep 8;5(14):1813-6. doi: 10.1097/00001756-199409080-00032.


Long-term depression of field excitatory postsynaptic potentials (EPSP) in the CA1 region of hippocampal slices was evoked by delivering a 15 min train of pulses at 1 Hz to the Schaffer-commissural-CA1 pathway, and prevented by adding an N-methyl-D-aspartate (NMDA) receptor antagonist (AP-5, 50 microM) to the perfusing medium. Superfusion of the slices with Cs (2 mM) during the 1 Hz stimulation period could both inhibit the maintenance phase of the depression itself and elicit spontaneous rhythmic activity. Cs had no effect on the postsynaptic response to the GABA-B agonist, baclofen. As a major effect of Cs is a block of the hyperpolarization-activated current (Ih), these results suggest the possible involvement of Ih in the maintenance of long-term depression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 2-Amino-5-phosphonovalerate / pharmacology
  • Animals
  • Cesium / pharmacology*
  • Depression, Chemical
  • Electric Stimulation
  • Hippocampus / cytology
  • Hippocampus / drug effects*
  • In Vitro Techniques
  • Male
  • Neuronal Plasticity / drug effects*
  • Neurons / drug effects*
  • Rats
  • Rats, Wistar
  • Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors


  • Receptors, N-Methyl-D-Aspartate
  • Cesium
  • 2-Amino-5-phosphonovalerate