Molecular and cellular basis of cancer invasion and metastasis: implications for treatment

Br J Surg. 1994 Nov;81(11):1576-90. doi: 10.1002/bjs.1800811107.


In the past decade significant advances in establishing the underlying biological mechanisms of tumour invasion and metastasis have been made. Some of the triggering factors and genes relevant to metastatic spread have been identified. Advances have also been made in understanding the signal transduction pathways involved in invasion and metastasis. This increased comprehension of the malignant metastatic process has enabled new antimetastatic strategies to be devised. This review summarizes progress in these areas and discusses the implications for the treatment of metastasis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Adhesion Molecules / physiology
  • Cell Movement
  • Humans
  • Neoplasm Invasiveness*
  • Neoplasm Metastasis* / genetics


  • Cell Adhesion Molecules