Regulation of proteolytic activity in tissues

Crit Rev Biochem Mol Biol. 1994;29(5):315-83. doi: 10.3109/10409239409083484.


Degradation of tissue proteins is controlled by multiple means. These include regulation of the synthesis of proteinases, activation of the zymogen forms, the activity of the mature proteinase, and the degradation of these enzymes and the substrates. Mature proteinases can be controlled by pH, calcium ions, ATP, lipids and the formation of complexes with other proteinases, proteoglycans, and inhibitors.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Cell Compartmentation
  • Cysteine Endopeptidases
  • Endopeptidases / biosynthesis
  • Endopeptidases / classification
  • Endopeptidases / drug effects
  • Endopeptidases / metabolism*
  • Enzyme Activation
  • Gene Expression Regulation, Enzymologic
  • Molecular Sequence Data
  • Multienzyme Complexes
  • Protease Inhibitors / pharmacology
  • Proteasome Endopeptidase Complex


  • Multienzyme Complexes
  • Protease Inhibitors
  • Endopeptidases
  • Cysteine Endopeptidases
  • Proteasome Endopeptidase Complex