In pursuit of a molecular mechanism for adaptive mutation

Genome. 1994 Dec;37(6):893-9. doi: 10.1139/g94-127.


An unexpected way of making mutations in bacteria has challenged concepts of the genetic mechanisms behind evolution for the past 6 years. Work on the molecular mechanism of these so called "adaptive" mutations is rapidly revealing a surprising and novel molecular mechanism, and it is altering our understanding of how mutations form in nondividing cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adaptation, Physiological / genetics*
  • Bacteria / genetics*
  • Biological Evolution
  • Models, Genetic
  • Mutation / physiology*
  • Recombination, Genetic*