Overrepresentation of the V kappa IV subgroup in light chain deposition disease

Immunol Lett. 1994 Sep;42(1-2):63-6. doi: 10.1016/0165-2478(94)90036-1.


The variability subgroup of human monoclonal kappa chains purified from urine in 3 consecutive patients with myeloma associated light chain deposition disease was determined from amino acid sequences of their first framework regions (FR1). N-glycosylation was searched for by N-glycosidase F treatment. These data together with our previously published results, indicate the pathogenic potential of the rare V kappa IV subgroup and confirm the absence of detectable serum and urine free monoclonal light chains when they are N-glycosylated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Bence Jones Protein / genetics
  • Electrophoresis, Polyacrylamide Gel
  • Glycosylation
  • Humans
  • Immunoglobulin A / isolation & purification*
  • Immunoglobulin kappa-Chains / isolation & purification*
  • Molecular Sequence Data
  • Multiple Myeloma / immunology*
  • Paraproteinemias / immunology*


  • Immunoglobulin A
  • Immunoglobulin kappa-Chains
  • Bence Jones Protein