Chondrodysplasia in five Great Pyrenees

J Am Vet Med Assoc. 1994 Sep 15;205(6):845-8.


Five disproportionate, short-limbed, short-trunked (dwarf) Great Pyrenees pups were examined. The mode of inheritance was compatible with a simple autosomal recessive trait, and skeletal radiography revealed flaring of the metaphyses of all long bones and the costochondral junctions of the ribs. Vertebral bodies were poorly ossified and short, and had a beak-like extension on the caudal metaphyseal margin. Vertebral body end-plates were thin and concave, and ossification was abnormal. Three of the 5 dogs were deaf, and 1 had testicular atrophy. Ocular examinations did not reveal any abnormalities. Histologic examination of the growth plates revealed disorganized chondrocyte columns, and chondrocytes appeared to have undergone degenerative changes in the zone of chondrocyte proliferation. Transmission electron micrography of growth plate chondrocytes revealed dilated profiles of rough endoplasmic reticulum.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Breeding
  • Cervical Vertebrae / diagnostic imaging
  • Dog Diseases / diagnostic imaging
  • Dog Diseases / genetics*
  • Dog Diseases / pathology
  • Dogs
  • Dwarfism / genetics
  • Dwarfism / pathology
  • Dwarfism / veterinary
  • Endoplasmic Reticulum / ultrastructure
  • Female
  • Forelimb / diagnostic imaging
  • Genes, Recessive
  • Growth Plate / pathology
  • Growth Plate / ultrastructure
  • Hindlimb / diagnostic imaging
  • Male
  • Microscopy, Electron
  • Osteochondrodysplasias / diagnostic imaging
  • Osteochondrodysplasias / genetics
  • Osteochondrodysplasias / pathology
  • Osteochondrodysplasias / veterinary*
  • Pedigree
  • Radiography