Adjunctive mitomycin C in Molteno implant surgery

Ophthalmology. 1995 Jan;102(1):91-7. doi: 10.1016/s0161-6420(95)31048-2.


Purpose: The authors assessed the efficacy of adjunctive intraoperative mitomycin C to produce lower intraocular pressures (IOPs) in patients with complicated glaucoma who underwent double-plate Molteno implantation.

Methods: A pilot series of 21 consecutive patients who underwent double-plate Molteno implantation with adjunctive intraoperative mitomycin C (0.5 mg/ml) for 5 minutes was compared with a historical control group who received Molteno implants without mitomycin C (n = 18). With failure defined as an IOP greater than 21 or less than 6 mmHg at two observations 1 month apart, the addition of medication, re-operation for glaucoma, or tube removal, a life-table analysis of IOP was performed on patients with at least 3 months' follow-up.

Results: Success in the mitomycin C group was higher (68% at 1 year) than the control group (17% at 1 year; P = 0.006). Loss of more than one line of vision (33%) and re-operation for complications (including flat anterior chamber, choroidal detachment, and tube blockage) (38%) were slightly but not significantly more frequent in the mitomycin C group than in the control group.

Conclusion: This study suggests that intraoperative mitomycin C in conjunction with Molteno implant may offer a better chance of achieving target IOPs in the low teens in patients with complicated glaucoma than Molteno implantation alone.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Aged
  • Female
  • Glaucoma / physiopathology
  • Glaucoma / surgery*
  • Humans
  • Intraocular Pressure
  • Intraoperative Care
  • Life Tables
  • Male
  • Middle Aged
  • Mitomycin / therapeutic use*
  • Molteno Implants*
  • Pilot Projects
  • Postoperative Complications
  • Reoperation
  • Treatment Outcome


  • Mitomycin