Adverse cardiac manifestations following dextropropoxyphene overdose: can naloxone be helpful?

Ann Emerg Med. 1995 Feb;25(2):263-6. doi: 10.1016/s0196-0644(95)70337-3.


Dextropropoxyphene overdose may be complicated by serious cardiovascular manifestations, including conduction abnormalities and collapse. We report two patients in whom cardiac toxicity developed. Cardiovascular depression seemed to be improved after naloxone infusion in these two cases. Possible mechanisms are briefly discussed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Arrhythmias, Cardiac / chemically induced
  • Arrhythmias, Cardiac / drug therapy*
  • Dextropropoxyphene / poisoning*
  • Drug Overdose / drug therapy
  • Female
  • Heart Block / chemically induced
  • Heart Block / drug therapy
  • Humans
  • Male
  • Middle Aged
  • Naloxone / therapeutic use*


  • Naloxone
  • Dextropropoxyphene