Plasma-prostaglandins in pre-term neonates before and after treatment for patient ductus arteriosus

Lancet. 1978 Jul 15;2(8081):130-2. doi: 10.1016/s0140-6736(78)91510-6.


9 pre-term babies with patent ductus arteriosus (P.D.A.) and cardiac failure were found to have significantly higher plasma-levels of three prostaglandins (P.G.E, P.G.F, and P.G.FM) than a group of normal pre-term infants of the same age. There was no difference in the plasma-prostaglandin levels before and after surgery in the 5 infants who underwent ligation of the ductus, suggesting that the high P.G. levels are not the result of a patent ductus, but that P.G.S may have a role in the pathogenesis of P.D.A. 3 infants who were treated by indomethacin (a P.G. synthetase inhibitor) showed a sharp initial drop in plasma-levels of the three P.G.S, but levels of P.G.F and P.G.FM had risen either during or within 48 h of completion of the course of indomethacin. These results may explain why high failure-rates have been reported for treatment of P.D.A. by indomethacin.

MeSH terms

  • Ductus Arteriosus, Patent / blood*
  • Ductus Arteriosus, Patent / complications
  • Ductus Arteriosus, Patent / drug therapy
  • Ductus Arteriosus, Patent / surgery
  • Heart Failure / etiology
  • Humans
  • Indomethacin / pharmacology
  • Indomethacin / therapeutic use
  • Infant, Newborn
  • Infant, Premature*
  • Prostaglandins / blood*
  • Prostaglandins E / blood
  • Prostaglandins F / blood


  • Prostaglandins
  • Prostaglandins E
  • Prostaglandins F
  • Indomethacin