Regulation of sex-hormone-binding globulin production by endogenous estrogens in vitro

Biochem Biophys Res Commun. 1995 Jan 26;206(3):895-901. doi: 10.1006/bbrc.1995.1127.

Abstract

The effect of endogenous estrogens on sex-hormone-binding globulin (SHBG) production was studied in HepG2 cells. 17 beta-estradiol, estrone, and estrogens from both 2- and 16 alpha-hydroxylative pathways stimulated SHBG production, but not in parallel with their binding affinities for the estrogen receptor. Thus, the underlying mechanism may be other than a pure interaction with the estrogen receptor.

MeSH terms

  • 2-Methoxyestradiol
  • Carcinoma, Hepatocellular
  • Estradiol / analogs & derivatives
  • Estradiol / metabolism
  • Estradiol / pharmacology
  • Estriol / pharmacology
  • Estrogens / metabolism
  • Estrogens / pharmacology*
  • Estrone / metabolism
  • Estrone / pharmacology
  • Humans
  • Hydroxyestrones / pharmacology
  • Liver Neoplasms
  • RNA, Messenger / metabolism
  • Receptors, Estrogen / metabolism
  • Sex Hormone-Binding Globulin / biosynthesis*
  • Sex Hormone-Binding Globulin / genetics
  • Tumor Cells, Cultured

Substances

  • Estrogens
  • Hydroxyestrones
  • RNA, Messenger
  • Receptors, Estrogen
  • Sex Hormone-Binding Globulin
  • 16-hydroxyestrone
  • Estrone
  • Estradiol
  • 2-Methoxyestradiol
  • 2-hydroxyestradiol
  • Estriol