Tumor-suppressor Gene Products in Cell Contacts: The cadherin-APC-armadillo Connection

Curr Opin Cell Biol. 1994 Oct;6(5):711-6. doi: 10.1016/0955-0674(94)90098-1.

Abstract

Various structural components of intercellular junctions have recently been found to represent (or be related to) products of tumor-suppressor genes. The tumor-suppressor gene product adenomatous polyposis coli (APC) binds to beta 2-catenin (homologous to the product of Drosophila armadillo), which is cytoplasmically associated with the cell adhesion molecule E-cadherin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adenomatous Polyposis Coli Protein
  • Animals
  • Armadillo Domain Proteins
  • Cadherins / genetics
  • Cadherins / physiology*
  • Cell Adhesion / genetics*
  • Cell Adhesion / physiology*
  • Cytoskeletal Proteins / genetics
  • Cytoskeletal Proteins / physiology
  • Drosophila
  • Drosophila Proteins*
  • Genes, APC
  • Genes, Tumor Suppressor*
  • Humans
  • Intercellular Junctions / physiology
  • Neoplasm Invasiveness
  • Proteins / genetics
  • Proteins / physiology
  • Trans-Activators*
  • Transcription Factors
  • beta Catenin

Substances

  • ARM protein, Drosophila
  • Adenomatous Polyposis Coli Protein
  • Armadillo Domain Proteins
  • CTNNB1 protein, human
  • Cadherins
  • Cytoskeletal Proteins
  • Drosophila Proteins
  • Proteins
  • Trans-Activators
  • Transcription Factors
  • beta Catenin